THE ARTHUS PHENOMENON

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The Arthus Phenomenon

An intense inflammatory reaction in the pericardium, heart, and intrapericardial aorta can regularly be produced in a sensitized rabbit by the intrapericardial injection of the homologous antigen.

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The Arthus Phenomenon Local Anaphylactic Inflammation in the Rabbit Brain

The brain as a functional unit in the production of generalized anaphylaxls has been extensively studied, notably by Besredka (1). As the seat of a local allergic reaction, however, it has apparently not yet been examined. Since the local anaphylactic reaction in the skin and in various organs (2) consists of edema, hemorrhage, and leucocytic infiltration, it appeared likely that the nervous ti...

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Attempts to Determine Whether the Secondary Reaction Is of Th~ Nature of an Arthus Phenomenon. By

In the preceding paper are described the lesions which follow the inoculation of certain non-hemolyt ic streptococci into the skin of the rabbit ; such lesions begin to decrease in size af ter 24 to 48 hours bu t in over 50 per cent of animals show a recrudescence of act iv i ty about the 8 th or 9th day. This phenomenon we have te rmed the secondary reaction. I t usually fails to occur in anim...

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The Effect of Egg Yolk in Diets on Anaphylactic Arthritis (passive Arthus Phenomenon) in the Guinea Pig

WHOLE EGG YOLK INCORPORATED AS A SUPPLEMENT IN THE DIET OF BABY GUINEA PIGS AFFORDED PROTECTION AGAINST ANAPHYLACTIC ARTHRITIS AS DETERMINED: (a) by measurement of joint swelling; (b) by the rise in serum level of some substance which reacts with diphenylamine; (c) by histologic examination. The active material in egg yolk was shown to be in the alcohol-soluble fraction. Attempts to identify th...

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Similarities in the Mechanisms Determining the Arthus and Shwartzman Phenomena

The intradermal injection of ovalbumin in rabbits sensitized to this antigen, under circumstances resulting in the elicitation of the Arthus phenomenon, causes a systemic reaction involving alterations in leucocytes and platelets, and results in cellular thrombosis of capillaries and veins in the injected skin areas. An abnormal metabolic process develops in the injected skin areas and may be t...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1932

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.55.1.163